Brainstem neurochemical profiles after hospitalisation for COVID-19: a 7T MR spectroscopy study.

There was also a positive trend for total choline ( β = 0.002; 95% CI 0.000 to 0.003, p = 0.055) in the patients ( Table 4 ).

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Whilst no significant differences were detected between the patients and controls, a measure of peak disease severity (maximum C-reactive protein assay value recorded during hospital admission) was correlated with myo -inositol concentration (a marker of glial activation) and showed a trend towards association with concentrations of choline-containing compounds (a potential marker of inflammation) in the brainstem.

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