Noncanonical target-strand cytosine base editing via engineered Un1Cas12f1 platform.

Nat Commun · 2025 · PMC12569094 · PMID 41152217

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did not reach statistical significanceno p-value reported

The higher dose led to a trend of more effective reduction of plasma transthyretin than the lower dose at 6 and 8 weeks after treatment, although the differences did not reach statistical significance.

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