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Association of Clopidogrel Genetic Polymorphism With Efficacy and Safety for Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Updated Meta-Analysis.

J Clin Neurol · 2025 · PMC12569420 · PMID 41151929

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In sensitivity analysis, across strata, carriers of CYP2C19 LoF alleles consistently had a higher risk of recurrent stroke or TIA than non-carriers, except in the ischemic stroke subtypes, where the point estimates trended higher but did not reach statistical significance ( Supplementary Fig. 9 in the online-only Data Supplement).

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