Role of Branched-Chain Amino Acids in Mitigating Osteosarcopenia: An Experimental Study Using Ovariectomised Mice Models.

J Cachexia Sarcopenia Muscle · 2025 · PMC12569608 · PMID 41159395

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RNA analysis in MLO‐Y4 osteocytic cells exposed to H 2 O 2 ‐induced oxidative stress revealed a significant increase in Sost (the gene encoding sclerostin) expression, while Wnt signalling–related genes ( Axin2 , Lef1 and Ctnnb ) showed a trend of compensatory upregulation, possibly reflecting a feedback response (Figure S4 ).

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