A clinically applicable method for early interstitial lung disease detection in incident rheumatoid arthritis cases: integration of protein biomarkers and clinical factors.

Although the absolute increase in the AUC for the combined detection (KL-6 + VWF + MMP-3) compared to KL-6 alone (ΔAUC = 0.03) did not reach statistical significance ( p = 0.129) with the current sample size, reclassification analysis demonstrated that the nomogram correctly identified nearly 10% of missed high-risk patients, underscoring its clinical added value.

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