ERC accumulation depletes Sir2 from rDNA and induces cellular senescence by rDNA destabilization.

Nucleic Acids Res · 2025 · PMC12571442 · PMID 41160898

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a decreasing trendno p-value reported

Sir2 localization levels at TEL07L showed a decreasing trend with aging; however, this decreasing trend was not statistically significant (Fig. 5B ).

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an increasing trendno p-value reported

did not reach statistical significanceno p-value reported

While H3K9 acetylation levels showed an increasing trend, they did not reach statistical significance ( Supplementary Fig.

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