A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry.

Several proteins displayed a positive trend across the phenotypes from NoAPS to MAPS ( Figure 1E , top panel), while others showed a negative trend ( Figure 1E , lower panel), suggesting an association with clinical severity of APS.

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Some of the proteins that were highly significant and discriminatory in severe types of APS included LTA4H, NAMPT, TNFRSF21, TF, SULT4A1, which can potentially be used as biomarkers, both diagnostic, for risk stratification of APS, as well as therapeutic targets.

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