Compared to the HC group, the frequency of IGHV4-34 usage was higher in the pSS group (median = 9.3% vs 3.9%), although the difference did not reach statistical significance (p = 0.100, Mann-Whitney U = 0.000) ( Figure 5C ).
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B cell subpopulations and their role in the pathogenesis of primary Sjögren's syndrome: insights from single-cell RNA sequencing.
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