Primary tumor sidedness and negative hyperselection to modulate anti-EGFR-based maintenance strategies in patients with RAS wild-type metastatic colorectal cancer: individual patient data pooled analysis of two randomized clinical trials.

As the remaining hyperselection definitions showed only a numerical trend, these findings underscore the predictive impact of BRAF V600E status in this subgroup.

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In contrast, analyses of the individual trial cohorts did not reach statistical significance for impact of these factors on maintenance treatment outcomes (Supplementary Table 7 ).

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