Applicability of phase 3 trial selection criteria to real-world transthyretin amyloid cardiomyopathy patients.

Sci Rep · 2025 · PMC12572294 · PMID 41162545

Europe PMC DOI

hedged sentence

0.0030

closest p · 0.1× alpha

0.0030

boldest claim

The sentences

failed to reach statistical significancep = 0.003actually significant

highly significantp = 0.003actually significant

While on a per-study level, this analysis failed to reach statistical significance, but for the proportion of ATTRv patients in ATTRACT, among the three trials, a highly significant tendency towards a higher proportion of male ( p = 0.003) and ATTRv ( p = 0.016) participants and was observed.

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