Colorectal-Specific Radiation Dose and Chemotherapy Risk for Subsequent Colorectal Malignancies in Childhood Cancer Survivors: A Childhood Cancer Survivor Study (CCSS) Report.

In unrestricted and restricted analyses, for nonprocarbazine alkylating agents, the yes/no effect was marginally significant, while the high-dose category (≥6,000 mg/m 2 ) was significant.

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We also assessed the effect of low dose to large volumes by considering V 5 Gy and V 10 Gy with maximum dose <20 Gy (V 20 Gy = 0% ) and did not observe a clear trend of colorectal SMN risk, which may be due to limited sample size (Data Supplement, Table S6).

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