The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.

ADAMTS-4 and ADAMTS-5 gene expression and protein synthesis The level of gene expression of ADAMTS-5 in OA cartilage determined by PCR analysis was highly variable and, although sometimes higher than that in normal cartilage, the differences did not reach statistical significance (Fig. 3 ).

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