Cognitive enrichment improves spatial memory and alters hippocampal synaptic connectivity in a mouse model for early-life stress.

Front Cell Neurosci · 2025 · PMC12575294 · PMID 41180497

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hedged sentences

0.0730

closest p · 1.5× alpha

0.0730

boldest claim

The sentences

approached significancep = 0.073so close (0.05 < p ≤ 0.1)

Sex effects approached significance for both mossy fiber area ( p = 0.073) and dentate gyrus area ( p = 0.079).

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a small trendno p-value reported

There was no significant group or sex difference in median cluster size [two-way ANOVA, group: F(1,8) = 4.36, p = 0.070; sex: F(1,8) = 0.0009, p = 0.976, Figure 4C ], although there was a small trend for smaller synapses in ELS + ET mice consistent with our distribution analysis.

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