Differential stress responses of immunoisolated human islets embedded in pancreatic extracellular matrix under static and free-fall dynamic conditions.

Glucose-stimulated insulin secretion was higher in dynamic culture compared to static culture when islets were challenged with ER-stressor, with the stimulation index rising by 2.23-fold ± 0.72 ( p = 0.0669) in alginate-only encapsulated islets and 1.43-fold ± 0.56 ( p = 0.8330) in alginate + ECM encapsulated islets, however, it did not reach statistical significance ( Figure 5(e) ).

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