Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia.

When primary microglia were incubated with fluorescently labeled endocytosis substrate Dextran (Dextran-Alexa Fluor 568) [ 35 ] and the lysosomal dye SiR, only Tecpr2 ki/ki microglia showed a trend in reduced intracellular Dextran and a significant decrease in SiR-positive puncta (Fig. 5 i, j).

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