A decrease in active osteoclastic surface (Oc.S/BS) in the FGF19 treatment group was noted, although it did not reach statistical significance ( p = .0648), even if osteoclast number over bone surface (Oc.N/BS, 1/μm) was actually higher in the FGF19 group ( p = .001; vehicle group: median: 3.63, min-max: 3.19-4.49, mean: 3.72, standard error of the mean: 0.10; FGF19 group: median: 4.64, min-max 4.10-10.43, mean: 5.59, standard error of the mean: 0.58).
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Therapeutic potential of FGF19 in combatting osteosarcopenia: effects on muscle strength and bone health in aged male mice.
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0.0648
0.0648