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Impact of glucocorticoid administration on therapeutic outcomes of immune checkpoint inhibitors in non-small cell lung cancer: a systematic review and meta-analysis.

Front Med (Lausanne) · 2025 · PMC12580123 · PMID 41189885

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In timing-based models (reference: pre-ICI exposure), post-ICI corticosteroid use showed a directionally positive association with both PFS and OS (larger HRs), consistent with our subgroup findings; however, coefficients did not reach statistical significance after Knapp–Hartung adjustment, and the reduction in between-study variance was modest.

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