Neutrophil proteins as potential biomarkers for a sputum-based tuberculosis screening test.

Finally, PDL-1 was selected because we had observed a highly significant upregulation of PDL-1 in sputum neutrophils of people with TB disease ( 15 ).

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However, all three neutrophil proteins were detectable in sputum and showed a trend for increased levels in asymptomatic TB cases compared to community controls, although this was not statistically significant ( Figure 4B ), and was not affected by method of TB diagnosis (not shown). 4 Discussion We investigated the potential of measuring sputum neutrophil proteins as a pre- screening test prior to expensive and time-consuming TB testing.

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