Increased ErbB2 Signaling Is an Early Adaptation to Androgen Signaling Inhibition and Persists in Castration-Resistant Prostate Cancer.

Both LNCaP and PC-1 xenografts showed significant increases in d16ERBB2 transcript expression at 7 days after castration, whereas VCaP xenografts showed a trend toward increased expression ( Fig. 4B ).

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Of interest, unlike the “oncogenic signatures” comparison of AER versus CRPC, which showed little difference between the two castration-resistant samples, Hallmark analysis comparing AER versus CRPC noted highly significant negative enrichments in several gene sets, including Epithelial_Mesenchymal_transition, Allograft_rejection, Inflammatory_response, and IFNγ_response (FDR q value < 0.00001 for all four gene sets).

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