Perioperative pembrolizumab in early-stage non-small cell lung cancer (NSCLC): conventional and distribution-based immune profiling of the tumor microenvironment and peripheral circulation.

17 There was a trend towards higher PD-L1 TPS scores in patients who demonstrated an MPR postoperatively; however, it did not reach statistical significance.

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Regarding tumor-associated T cells, there appears to be an overall trend wherein MPR tumors harbor the lowest mean CD4 + cell frequencies compared with “PR” and “SOR” tumors, and highest mean CD8 + frequencies among the three groups ( figure 1a ).

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This novel distribution-based analytic platform identified highly significant baseline peripheral blood mononuclear cell immune cell subsets putatively associated with major pathologic responses following neoadjuvant pembrolizumab therapy.

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