Mesenchymal stem cells-derived exosomes and Kaempferol improve myelin repair via attenuating inflammation and oxidative stress in a cuprizone-induced demyelination model.

Although the treated groups also exhibited an increase, the change did not reach statistical significance compared with that of the CPZ + Vehicle group ( P = 0.0009) (interaction F (8, 50) = 3.850, P = 0.0014; time F (1.876, 46.91) = 17.61, P < 0.0001; treatment F (4, 25) = 8.022, P = 0.0003; Fig. 2 D).

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The latency test on day 74 revealed a highly significant difference between the intact and CPZ + Vehicle groups, indicating that CPZ induced motor coordination impairment.

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