NeuproGemp, a polyphenol-rich botanical formula, ameliorates Alzheimer's-like pathology in APP/PS1 mice via inhibition of human glutaminyl cyclase.

0.55 ± 0.15) ( Figure 1C ), indicating a trend toward enhanced recognition memory that did not reach statistical significance under current experimental conditions.

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3 Results 3.1 NeuproGemp improves ethological behavior in APP/PS1 mice In 5-month-old APP/PS1 transgenic mice, 6 weeks of daily oral NeuproGemp treatment (300 mg/kg/day) ( Figure 1A ) led to a marked improvement in ethologically relevant behavior, as shown in the burrowing assay: NeuproGemp-treated mice displaced ∼150 ± 25 g of substrate compared to ∼60 ± 40 g in vehicle controls—a highly significant enhancement ( Figure 1B ).

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