Barely Significant
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Investigation of 6-thioguanine as a strategy to overcome methotrexate resistance in a mouse model of leptomeningeal carcinomatosis.

J Neurooncol · 2025 · PMC12583346 · PMID 41182443

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showed a trendp = 0.050actually significant
Administration at 6 h showed a trend toward longer survival ( p = 0.050), whereas administration at 12 h resulted in shorter survival compared with concurrent treatment (Fig. 5 c).

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