Synovial matrix turnover controls immune cell spatial patterning in inflammation resolution.

However, a significant positive correlation was observed between the COL6A1+ perivascular area and the combined proportion of MerTK+ macrophages and T cells (Benjamini–Hochberg adjusted P = 0.029), with a trend towards significance for MerTK + macrophages alone (Benjamini–Hochberg adjusted P = 0.055) (Appendix Fig.

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Although numbers of patients of each CTAP are small ( n = 3 CTAP:T + F, n = 5 all other CTAP) there is a clear trend showing increased expression of collagens 1, 3 and 6, but not COL14, in lining fibroblasts of RA patients with a CTAP:M phenotype, and COL6A1 was significantly upregulated between RA CTAP:M and OA patients (Appendix Fig.

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