Comprehensive genomic profiling of breast cancer reveals mutational landscape and the PEEKABOO model: a population-specific assessment tool for predicting germline mutations.

Multivariate analysis indicated gHRRm (OR, 2.53; 95% CI, 1.06–6.32; p = 0.041; Table 7 ) as an independent predictive factor of pCR in patients with TNBC, whilst gBRCA1/2m showed borderline significance (OR, 2.18; 95% CI, 0.84–6.02; p = 0.118; Table 8 ).

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Furthermore, our study suggested that TNBC patients receiving immunotherapy combined with chemotherapy showed a trend towards pCR increase in the gHRR mutation group, although the difference was not statistically significant.

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