Prognostic impact of extranodal extension in oral cavity cancers: a retrospective analysis and implications for treatment intensification.

Although the overall results did not reach statistical significance, a trend toward improved DFS was observed in patients with multiple high-risk features—including T3–T4 primaries, N2–N3 nodes, and ENE.

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Variables such as male sex, tobacco use, lip subsite involvement, and skin or bony invasion showed a trend toward significance (Fig. 2 ).

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