A machine learning-based method to optimize the immunogenicity of human leukocyte antigen class I-restricted neoantigens.

Brief Bioinform · 2025 · PMC12586337 · PMID 41189382

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did not reach statistical significanceno p-value reported

However, Naso’s superiority over Aomp and Mobius on HLA-C did not reach statistical significance based on the NeoaPred metric, potentially attributable to limited power from the small HLA-C subset (N < 40) or inherent HLA-C immunogenicity prediction challenges.

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