Integrative multi-omics deciphers the potential mechanism and microbial biomarkers for lymph node metastasis in colorectal cancer.

Consistent with our observation, another study observed a decreasing trend in the composition of Proteobacteria as CRC progresses 35 .

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Strikingly, the phylum Proteobacteria, unassigned ( p _PU) and the order Corynebacteriales ( o _CB) presented significantly higher proportions in tumor tissues compared to the adjacent normal tissues through taxonomy evaluation ( p = 0.040 and p = 0.003, respectively), although the α-diversity and the β-diversity between the groups did not reach statistical significance.

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