Global trends and health system impact on polycystic ovary syndrome: a comprehensive analysis of age-stratified females from 1990 to 2021.

Front Reprod Health · 2025 · PMC12588920 · PMID 41210405

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a positive trendno p-value reported

From 1990 to 2021, a positive trend annually in the global ASIR and ASPR of PCOS was observed in the time cohort.

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a negative trendno p-value reported

In contrast to the high ASIR, high-income North America had the lowest EAPC value of incidence rate, which was −0.56 (95% CI: −1.04 to −0.08) and a negative trend, suggesting that the incidence of patients with PCOS is slowly decreasing.

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a decreasing trendno p-value reported

Regionally, only Tropical Latin America [EAPC −0.22 (95% CI: −0.4 to −0.05)] showed a decreasing trend ( Table 1 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.