Investigating Disruptions in Information Flow due to Sickle Cell Disease Using Granger Causality.

While the global average F ‐value, representing effective connectivity, was elevated in patients with SCD compared to controls, this difference did not reach statistical significance (controls: mean [SEM] = 3.82 [2.13]; SCD: mean [SEM] = 4.03 [2.86]; corrected p > 0.05), as shown in Figure S1c .

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