Interplay between red blood cells and circulating tumor cells: clinical and molecular evidence of a putative pro-metastatic axis.

Primary tumors seeding CTC RBC ( n = 4) expressed higher levels of ADAM1TS (log2FC = 2.11), and lower levels of CCL5 and CD34 (log2FC = −0.78 and log2FC = −1.17, respectively), in comparison to those seeding CTCs not clustering with erythrocytes ( n = 4), however, those changes did not reach statistical significance (all p = 0.133).

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