Impact of Comorbidity Burden on Clinical Outcomes in Older Adults With Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis.

Cureus · 2025 · PMC12593144 · PMID 41210033

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a nonsignificant trendno p-value reported

In contrast, pooled analyses found no clear association between comorbidity burden and PFS (pooled HR 1.00, 95% CI 0.89-1.14) and only a nonsignificant trend toward more treatment-related AEs in high-CCI groups (pooled HR 1.73, 95% CI 0.79-3.79).

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did not reach statistical significanceno p-value reported

The pooled analysis demonstrated a trend toward higher risk of AEs in patients with higher CCI scores; however, the association did not reach statistical significance (pooled HR = 1.73, 95% CI: 0.79-3.79; k = 2).

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