Engineered probiotic restores GLP-1 signaling to ameliorate fiber-deficiency exacerbated colitis.

Sci Adv · 2025 · PMC12594200 · PMID 41202140

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did not reach statistical significanceno p-value reported

While the reduction in Gcg expression showed a consistent trend but did not reach statistical significance, the marked down-regulation of Pcsk1 suggests impaired processing of proglucagon to active GLP-1.

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