Permanent Senescence Via p16 Leads to Guttae Formation in an In Vitro Human Corneal Endothelial Cell Model.

Invest Ophthalmol Vis Sci · 2025 · PMC12594260 · PMID 41182030

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

did not reach statistical significanceP = 0.07so close (0.05 < p ≤ 0.1)

Although COL8A2 (37-fold) and LAMA3 (84-fold) also showed upregulation, these changes did not reach statistical significance ( P = 0.07 and P = 0.06, respectively; Fig. 4 B).

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