Cellular activity upregulation of the thermolabile p53 cancer mutant Y220C by small molecule indazole derivatives.

In MCF7 p53-Y220C cells, all three compounds (JC16, JC36, and JC65) induced elevated levels of apoptosis compared to the control, although the changes did not reach statistical significance (Fig. 5B, D ), potentially due to cell line-specific differences in mutant p53 expression and signaling context.

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