Barely Significant
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Single-molecule characterization of opioid receptor heterodimers reveals soluble µ-δ dimer blocker peptide alleviates morphine tolerance.

Nat Commun · 2025 · PMC12594925 · PMID 41203592

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quite significantno p-value reported
M* DAMGO monomer/homodimer internalization would occur much less efficiently at the level of individual molecules, but since larger fractions of M* DAMGO exist as monomers at any moment, the overall contributions of M* DAMGO monomers/homodimers to M* DAMGO internalization are quite significant (Fig. 9c ).

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