Identification and external validation of a prognostic signature based on hypoxia-glycolysis-related genes for kidney renal clear cell carcinoma.

The integration of the risk model constructed by HGRGs yielded a numerically higher, but not statistically significant, C-index (0.769, 95% CI: 0.734–0.804) and showed a trend toward improved discriminative ability versus omitting it (C-index = 0.759, 95% CI: 0.723–0.795) ( Figure 7d and e ). 3.5 Enrichment analysis KEGG enrichment analysis identified several functions associated with the five HGRGs, including glycolysis/gluconeogenesis, carbon metabolism, etc.

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