Characteristics of ectopic alveolar basal cells relative to airway basal cells in fibrosis.

Interestingly, alveolar BC showed a trend towards reduced expression of BC markers and keratinisation genes and increased expression of EMT genes and mesenchymal markers, although to a lesser extent than the aberrant basaloid cells [ 1 , 2 ].

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scRNA-seq analysis revealed an overall trend, although not significant, towards reduced BC marker gene expression in alveolar BC, which was, however, not accompanied by expression of specific AT2 cell marker genes.

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