Pathobiology of the autophagy-lysosomal pathway in the Huntington's disease brain.

Acta Neuropathol Commun · 2025 · PMC12598841 · PMID 41204380

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a strong trendp = 0.06so close (0.05 < p ≤ 0.1)

In addition, analysis of ubiquitination revealed a significant increase in K 48 and K 63 ubiquitination and a strong trend of elevation in Total ubiquitination (p = 0.06) in the STR and a significant increase only in K 48 ubiquitination in the CTX (Fig. 3 A, B and E), implying that there might be a compensatory but still impaired response of the UPS to protein aggregates, whereas CBM is largely unchanged (Suppl.

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