Effect of ACT001 on bile acid–related mRNA expression of MASLD mice In the HFD-induced model, ACT001/PPC treatment showed a trend toward reducing ileal FXR mRNA expression in HFD mice, although the difference was not statistically significant ( p > 0.05) ( Figure 11A ).
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ACT001 alleviates MASLD through gut microbiota-bile acid-FXR axis in mice.
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