A Comparative Evaluation of Midazolam, Ketamine and Their Combination as Sedative Agents in Pediatric Dentistry: A Systematic Review and Meta-analysis.

Front Dent · 2025 · PMC12599264 · PMID 41220801

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an increasing trendno p-value reported

The meta-analysis, involving three RCTs with 215 children, indicated an increasing trend in treatment duration up to 0.8 mg/kg dosage of oral midazolam.

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did not reach statistical significanceno p-value reported

They observed that the percentage of children who did not cry was consistently higher in the group receiving midazolam-ketamine compared to the group receiving midazolam alone, but this difference did not reach statistical significance.

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