Mendelian Randomization Reveals Unidirectional Links Between Amyloid-β and Tau in Alzheimer's Disease.

Dement Neurocogn Disord · 2025 · PMC12599413 · PMID 41220873

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closest p · 0.0× alpha

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did not reach statistical significancep =0.001actually significant

However, MR-Egger, simple mode, and weighted mode methods showed similar coefficient trends but did not reach statistical significance The CAUSE method further validated the causal relationship between Aβ accumulation and CSF pTau levels ( p =0.001).

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