A systems toxicology approach implicates post-transcriptional regulatory networks in reproductive defects from PFAS exposure.

Linear regression modeling indicated there was an increasing trend in relative bend: pachytene dpMPK-1 intensity with both increasing PFOS (F(1, 10) = 18.13, adjusted R 2 = 0.61, P = 0.002) and 6:2 Cl-PFESA (F(1, 10)=11.29, adjusted R 2 = 0.48, P = 0.007) concentrations.

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Based on linear regression modeling, PFOS exposure caused a decreasing trend in total viable brood size (F(1,10)=9.22, adjusted R 2 =0.43; P = 0.01) ( Fig. 2C ). 6:2 Cl-PFESA exposure led to a similar decreasing trend in total viable brood size (F(1,10)=6.43, adjusted R 2 =0.33; P = 0.03) ( Fig. 2D ).

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Group-based comparisons did not reach statistical significance.

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