Sex-Related Differences in Histone Acetylation and Tumor Development in a 4-Nitroquinoline 1-Oxide and Ethanol-Induced Oral Squamous Cell Carcinoma Mouse Model.

Combining 4NQO with EtOH resulted in increased KAT2A expression compared to EtOH or 4NQO alone, although this increase did not reach statistical significance (Figure 4G,H ).

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In the 4NQO/H 2 O group, OSCC‐bearing males had a higher H3K9ac expression than the other lesions, though it did not achieve significance (Figure 1E ).

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