Differential effects of lithium on metabolic dysfunctions in astrocytes derived from bipolar disorder patients.

Mol Psychiatry · 2025 · PMC12602366 · PMID 40847005

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a decreasing trendno p-value reported

did not reach statistical significanceno p-value reported

Another study has shown a decreasing trend of respiration in neural progenitor cells (NPCs) derived from BD patients’ iPSCs, although the results did not reach statistical significance [ 18 ].

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an increasing trendno p-value reported

Furthermore, only BD iAstrocytes from Li-R patients showed a significant increase in glycolytic PER (glycoPER); BD iAstrocytes from Li-NR patients did not exhibit a significant change despite an increasing trend (Fig. 3d , Supplementary Fig.

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