Efficacy and Safety of Nerinetide in Acute Ischemic Stroke Patients: A Systematic Review, Meta-Analysis and Meta Regression.

Brain Behav · 2025 · PMC12602456 · PMID 41214902

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0519

boldest claim

The sentences

borderline significantp = 0.05actually significant

Nerinetide showed a borderline significant mortality reduction versus placebo (RR = 0.86; 95% CI 0.75–1.00; p = 0.05) with low heterogeneity ( I 2 = 11%).

also in 6,181 other papers

marginally significantp = 0.0519so close (0.05 < p ≤ 0.1)

Among them, atrial fibrillation showed a positive association with the risk of death (coefficient = 0.0142; p = 0.0489), while any past stroke also demonstrated a positive and marginally significant association (coefficient = 0.0259; p = 0.0519).

also in 13,554 other papers

did not reach statistical significanceno p-value reported

Although this difference did not reach statistical significance, the trend warrants attention.

also in 61,332 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.