Furthermore, heterogeneity tests for the differences in effect sizes between these subgroups did not reach statistical significance, findings that align with those reported by Ul et al.
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The efficacy and safety of tislelizumab in the treatment of locally advanced or metastatic lung cancer: a systematic review and meta-analysis.
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Similarly, the lack of a statistically significant improvement in OS and PFS in our RCT analysis, despite a positive trend, echoes the nuanced results seen in some earlier meta-analyses of immunotherapy, where benefits were sometimes confined to specific subgroups or required longer follow-up to become apparent ( Chen et al., 2018 ; Peng and Wu, 2019 ).