At 9 months, the ubiquitin ligase MUSA1 was significantly upregulated in the KO muscle, while the upregulation of Atrogin1 , MuRF1 , FoxO3 , and FoxO4 in KO muscle was nearly significant (Fig. 5I ).
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Alterations in peroxisome-mitochondria interplay in skeletal muscle accelerate muscle dysfunction.
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