Antibody-drug conjugates in HER2-positive advanced or metastatic gastric cancer: a systematic review and meta-analysis.

Front Oncol · 2025 · PMC12605428 · PMID 41234730

Europe PMC DOI

hedged sentences

0.0629

closest p · 1.3× alpha

0.0629

boldest claim

The sentences

marginally significantp = 0.0629so close (0.05 < p ≤ 0.1)

Begg’s test was marginally significant (Kendall’s tau = -0.4242, p = 0.0629).

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a significant trendno p-value reported

Among the evaluated agents, Trastuzumab deruxtecan (T-DXd) has demonstrated excellent and robust efficacy across multiple clinical studies we included (including a pivotal phase I study, DS8201-A-J101, and multiple phase II/III trials, DESTINY-Gastric01, DS8201-A-U205, DESTINY-Gastric04), showing a significant trend of ORR improvement with moderate intra-subgroup heterogeneity.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.