The role of cancer stem cells in the progression of colorectal cancer and the tumor microenvironment: new perspectives from single-cell RNA sequencing and spatial transcriptomics analyses.

We used SPATA spatial trajectory analysis to define an arrow in a direction from the low CSS score region to the high score region, and found that the WNT signaling pathway score table showed a trend similar trend to the CSS score ( Figure 7I ).

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What is known and what is new? • CSCs are closely associated with the progression of cancer, making the study of CSCs highly significant for the discovery of new therapeutic strategies. • We identified a colorectal cancer stem cell subtype associated with tumor progression and uncovered the characteristic genes NPDC1 and NSMF that are indicative of poor prognosis in colorectal cancer patients.

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